Salmonellainfection inhibits intestinal biotin transport: cellular and molecular mechanisms
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چکیده
منابع مشابه
Salmonella infection inhibits intestinal biotin transport: cellular and molecular mechanisms.
Infection with the nontyphoidal Salmonella is a common cause of food-borne disease that leads to acute gastroenteritis/diarrhea. Severe/prolonged cases of Salmonella infection could also impact host nutritional status, but little is known about its effect on intestinal absorption of vitamins, including biotin. We examined the effect of Salmonella enterica serovar Typhimurium (S. typhimurium) in...
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The water-soluble vitamin biotin is essential for normal cellular functions and its deficiency leads to a variety of clinical abnormalities. Mammals obtain biotin from exogenous sources via intestinal absorption, a process mediated by the sodium-dependent multivitamin transporter (SMVT). Chronic alcohol use in humans is associated with a significant reduction in plasma biotin levels, and animal...
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Inhibition of intestinal biotin absorption by chronic alcohol feeding: 1 Cellular and molecular mechanisms 2 Sandeep B. Subramanya, Veedamali S. Subramanian, Jeyan S. Kumar, Robert Hoiness, and 3 Hamid M. Said 4 Departments of Medicine and Physiology/Biophysics, University of California, Irvine, CA 92697, 5 and 6 Department of Veterans Affairs Medical Center, Long Beach, CA 90822 7 8 9 Running ...
متن کاملMolecular mechanism of the intestinal biotin transport process.
Previous studies have characterized different aspects of the cellular/membrane mechanism and regulation of the intestinal uptake process of the water-soluble vitamin biotin. Little, however, is known about the molecular mechanisms of the uptake process. In this study, we have identified a cDNA from rat small intestine that appears to be involved in biotin transport. The open reading frame of th...
متن کاملSymposium: Nutrition, Biochemistry and Molecular Biology of Biotin Cellular Uptake of Biotin: Mechanisms and Regulation
This review describes our knowledge of biotin transport in the small intestine of humans and other mammals and presents recent findings in the area. Previous studies have shown that biotin transport across the brush border membrane of the small intestinal absorptive cells occurs via a carrier-mediated, Na gradientdependent, electroneutral mechanism. Exit of biotin out of the enterocyte, i.e., t...
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ژورنال
عنوان ژورنال: American Journal of Physiology-Gastrointestinal and Liver Physiology
سال: 2015
ISSN: 0193-1857,1522-1547
DOI: 10.1152/ajpgi.00112.2015